Dr. Don Sin Bio
Dr. Sin is a chest physician and a clinical epidemiologist, who works primarily with large databases. In close collaboration with Dr. Paul Man, he also conducts research using a "wet" laboratory to analyze serum samples from chronic obstructive pulmonary disease (COPD) patients for various markers/mediators of systemic inflammation to better understand the link between COPD and cardiovascular diseases.
Dr. Sin graduated from the University of Alberta in 1991 (MD), and specialized in Internal Medicine and became certified in Respirology in 1997. He obtained an MPH degree at Harvard University and did his post-clinical training at University of Toronto.
His major areas of research interest include:
evaluating novel therapies for management of patients with COPD, with an emphasis on anti-inflammatory agents. evaluating novel biomarkers of systemic inflammation in COPD patients evaluating the potential role of systemic inflammation in the pathogenesis of cardiovascular complications among COPD patients
Chronic obstructive pulmonary disease (COPD), comprising chronic bronchitis and emphysema, is a major cause of illness and death worldwide. It is the fourth leading cause of premature mortality in Canada, causing approximately 10,000 Canadians to die annually. Statistics Canada shows an increasing rate of hospital usage and mortality for the disease. In addition, there is evidence that patients who smoke and develop COPD are at increased risk of cardiac disease and sudden death from heart attacks.
Dr. Don Sin is a specialist in respiratory medicine with advanced training in public health from Harvard University and is an expert in population health administrative databases. As the Canada Research Chair in Chronic Obstructive Pulmonary Disease, Dr. Sin is examining the relationships between smoking and COPD and cardiovascular disease as well as COPD drug therapies. There is increasing evidence that inhaled medications, particularly steroids, can influence the severity and progression of COPD and perhaps influence cardiovascular disease.
Dr. Sin's recent work shows that smokers who develop emphysema and chronic bronchitis have elevated levels of proteins in the blood, which are predictors of heart disease. He is exploring this relationship using a combination of population based research, clinical research, and laboratory testing of levels of these proteins in the blood.
Dr. Sin's objective is to decrease the individual and societal impact of the lung and heart diseases that are associated with smoking and industrial pollution. His research ranges from the study of molecular interaction to the societal impact of these disorders. Knowledge gained from this research will help basic science researchers and health-care professionals, as well as health-care policy makers.
( Dr. Don Sin, Respirologist, Vancouver, BC ) is in good standing with the College of Physicians and Surgeons.
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